HMM Summary Page: TIGR02820

FunctionS-(hydroxymethyl)glutathione synthase
Gene Symbolgfa
Trusted Cutoff234.55
Domain Trusted Cutoff234.55
Noise Cutoff135.65
Domain Noise Cutoff135.65
Isology Typeequivalog
EC Number4.4.1.22
HMM Length182
Mainrole CategoryCellular processes
Subrole CategoryDetoxification
Gene Ontology TermGO:0046292: formaldehyde metabolic process biological_process
GO:0051907: S-(hydroxymethyl)glutathione synthase activity molecular_function
AuthorHaft DH
Entry DateFeb 9 2006 10:08PM
Last ModifiedFeb 14 2011 3:27PM
CommentThe formation of S-(hydroxymethyl)glutathione synthase from glutathione and formaldehyde occurs naturally, but this enzyme speeds its formation in some species as part of a pathway of formaldehyde detoxification.
ReferencesRN [1] RM 11741920 RT A glutathione-dependent formaldehyde-activating enzyme (Gfa) from Paracoccus denitrificans detected and purified via two-dimensional proton exchange NMR spectroscopy. RA Goenrich M, Bartoschek S, Hagemeier CH, Griesinger C, Vorholt JA. RL J Biol Chem. 2002 Feb 1;277(5):3069-72. DR HAMAP; MF_00723; 13 of 13
Genome PropertyGenProp0562: formaldehyde detoxification, glutathione-dependent (HMM)