|Domain Trusted Cutoff||281.70|
|Domain Noise Cutoff||131.95|
|Mainrole Category||Cellular processes|
|Gene Ontology Term||GO:0018738: S-formylglutathione hydrolase activity molecular_function|
| ||GO:0046292: formaldehyde metabolic process biological_process|
|Entry Date||Feb 9 2006 10:59PM|
|Last Modified||Feb 14 2011 3:27PM|
|Comment||This model describes a protein family from bacteria, yeast, and human, with a conserved critical role in formaldehyde detoxification as S-formylglutathione hydrolase (EC 188.8.131.52). Members in eukaryotes such as the human protein are better known as esterase D (EC 184.108.40.206), an enzyme with broad specificity, although S-formylglutathione hydrolase has now been demonstrated as well.|
RT S-formylglutathione hydrolase of Paracoccus denitrificans is homologous to human esterase D: a universal pathway for formaldehyde detoxification?
RA Harms N, Ras J, Reijnders WN, van Spanning RJ, Stouthamer AH.
RL J Bacteriol. 1996 Nov;178(21):6296-9.|
|Genome Property||GenProp0562: formaldehyde detoxification, glutathione-dependent (HMM)|
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