HMM Summary Page: TIGR02821

FunctionS-formylglutathione hydrolase
Gene SymbolfghA
Trusted Cutoff281.70
Domain Trusted Cutoff281.70
Noise Cutoff131.95
Domain Noise Cutoff131.95
Isology Typeequivalog
EC Number3.1.2.12
HMM Length275
Mainrole CategoryCellular processes
Subrole CategoryDetoxification
Gene Ontology TermGO:0018738: S-formylglutathione hydrolase activity molecular_function
GO:0046292: formaldehyde metabolic process biological_process
AuthorHaft DH
Entry DateFeb 9 2006 10:59PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis model describes a protein family from bacteria, yeast, and human, with a conserved critical role in formaldehyde detoxification as S-formylglutathione hydrolase (EC Members in eukaryotes such as the human protein are better known as esterase D (EC, an enzyme with broad specificity, although S-formylglutathione hydrolase has now been demonstrated as well.
ReferencesRN [1] RM 8892832 RT S-formylglutathione hydrolase of Paracoccus denitrificans is homologous to human esterase D: a universal pathway for formaldehyde detoxification? RA Harms N, Ras J, Reijnders WN, van Spanning RJ, Stouthamer AH. RL J Bacteriol. 1996 Nov;178(21):6296-9.
Genome PropertyGenProp0562: formaldehyde detoxification, glutathione-dependent (HMM)