HMM Summary Page: TIGR02826

AccessionTIGR02826
NameRNR_activ_nrdG3
Functionanaerobic ribonucleoside-triphosphate reductase activating protein
Gene SymbolnrdG
Trusted Cutoff151.70
Domain Trusted Cutoff151.70
Noise Cutoff77.35
Domain Noise Cutoff77.35
Isology Typeequivalog
EC Number1.97.1.-
HMM Length148
Mainrole CategoryPurines, pyrimidines, nucleosides, and nucleotides
Subrole Category2'-Deoxyribonucleotide metabolism
Gene Ontology TermGO:0008998: ribonucleoside-triphosphate reductase activity molecular_function
GO:0008998: ribonucleoside-triphosphate reductase activity molecular_function
GO:0008998: ribonucleoside-triphosphate reductase activity molecular_function
GO:0009265: 2'-deoxyribonucleotide biosynthetic process biological_process
GO:0009265: 2'-deoxyribonucleotide biosynthetic process biological_process
GO:0009265: 2'-deoxyribonucleotide biosynthetic process biological_process
GO:0043364: catalysis of free radical formation molecular_function
GO:0043364: catalysis of free radical formation molecular_function
GO:0043364: catalysis of free radical formation molecular_function
GO:0051536: iron-sulfur cluster binding molecular_function
GO:0051536: iron-sulfur cluster binding molecular_function
GO:0051536: iron-sulfur cluster binding molecular_function
AuthorHaft DH
Entry DateFeb 17 2006 10:26AM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this family represent a set of radical SAM enzymes related to, yet architecturally different from, the activating protein for the glycine radical-containing, oxygen-sensitive ribonucleoside-triphosphate reductase (RNR) as described in model TIGR02491. Members of this family are found paired with members of a similarly divergent set of anaerobic ribonucleoside-triphosphate reductases. Identification of this protein as an RNR activitating protein is partly from pairing with a candidate RNR. It is further supported by our finding that upstream of these operons are examples of a conserved regulatory element (described Rodionov and Gelfand) that is found in nearly all bacteria and that occurs specifically upstream of operons for all three classes of RNR genes.
ReferencesDR TIGRFAMs; TIGR02491; anaerobic ribonucleoside-triphosphate reductase activating protein. RN [1] RM 15949864 RT Identification of a bacterial regulatory system for ribonucleotide reductases by phylogenetic profiling. RA Rodionov DA, Gelfand MS. RL Trends Genet. 2005 Jul;21(7):385-9.
Genome PropertyGenProp0291: class III (anaerobic) ribonucleotide reductase (HMM)
GenProp0291: class III (anaerobic) ribonucleotide reductase (HMM)
GenProp0291: class III (anaerobic) ribonucleotide reductase (HMM)
GenProp0291: class III (anaerobic) ribonucleotide reductase (HMM)
GenProp0291: class III (anaerobic) ribonucleotide reductase (HMM)
GenProp0291: class III (anaerobic) ribonucleotide reductase (HMM)