HMM Summary Page: TIGR02846

FunctionRNA polymerase sigma-K factor
Gene SymbolsigK
Trusted Cutoff298.65
Domain Trusted Cutoff298.65
Noise Cutoff278.75
Domain Noise Cutoff278.75
Isology Typeequivalog
HMM Length227
Mainrole CategoryTranscription
Subrole CategoryTranscription factors
Gene Ontology TermGO:0006352: transcription initiation, DNA-dependent biological_process
GO:0016987: sigma factor activity molecular_function
GO:0042173: regulation of sporulation resulting in formation of a cellular spore biological_process
AuthorHaft DH
Entry DateFeb 28 2006 1:43PM
Last ModifiedFeb 14 2011 3:27PM
CommentThe sporulation-specific transcription factor sigma-K (also called sigma-27) is expressed in the mother cell compartment of endospore-forming bacteria such as Bacillus subtilis. Like its close homolog sigma-E (sigma-29) (see TIGR02835), also specific to the mother cell compartment, it must be activated by a proteolytic cleavage. Note that in Bacillus subtilis (and apparently also Clostridium tetani), but not in other endospore forming species such as Bacillus anthracis, the sigK gene is generated by a non-germline (mother cell only) chromosomal rearrangement that recombines coding regions for the N-terminal and C-terminal regions of sigma-K.
Genome PropertyGenProp0610: endospore formation marker gene set (HMM)