HMM Summary Page: TIGR02875

Functionsporulation transcription factor Spo0A
Gene Symbolspo0A
Trusted Cutoff200.00
Domain Trusted Cutoff195.00
Noise Cutoff180.00
Domain Noise Cutoff180.00
Isology Typeequivalog
HMM Length262
Mainrole CategoryCellular processes
Subrole CategorySporulation and germination
Gene Ontology TermGO:0000156: two-component response regulator activity molecular_function
GO:0000160: two-component signal transduction system (phosphorelay) biological_process
GO:0006355: regulation of transcription, DNA-dependent biological_process
GO:0030436: asexual sporulation biological_process
GO:0042173: regulation of sporulation resulting in formation of a cellular spore biological_process
AuthorHaft DH
Entry DateMar 8 2006 9:51AM
Last ModifiedMar 6 2011 12:57PM
CommentSpo0A, the stage 0 sporulation protein A, is a transcription factor critical for the initiation of sporulation. It contains a response regulator receiver domain (PF00072). In Bacillus subtilis, it works together with response regulator Spo0F and the phosphotransferase Spo0B, both of which are missing from at least some sporulating species and thus not part of the endospore forming bacteria minimal gene set. Spo0A, however, is universal among endospore-forming species.
ReferencesDR PFAM; PF00072; Response_reg RN [1] RM 16420367 RT Phosphorylation and functional analysis of the sporulation initiation factor Spo0A from Clostridium botulinum. RA Worner K, Szurmant H, Chiang C, Hoch JA. RL Mol Microbiol. 2006 Feb;59(3):1000-12.
Genome PropertyGenProp0610: endospore formation marker gene set (HMM)