HMM Summary Page: TIGR02921
| Accession | TIGR02921 |
| Name | PEP_integral |
| Function | PEP-CTERM family integral membrane protein |
| Trusted Cutoff | 200.00 |
| Domain Trusted Cutoff | 200.00 |
| Noise Cutoff | 100.00 |
| Domain Noise Cutoff | 100.00 |
| Isology Type | hypoth_equivalog |
| HMM Length | 922 |
| Author | Haft DH, Selengut J |
| Entry Date | Apr 21 2006 2:28PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | Members of this protein family, found in eighteen genera so far, have a PEP-CTERM sequence at the carboxyl-terminus (see model TIGR02595), but are unusual among PEP-CTERM proteins in having multiple predicted transmembrane segments. The function is unknown. It is proposed that an exosortase (see TIGR02602), recognizes and cleaves PEP-CTERM proteins in a manner analogous to the cleavage of LPXTG proteins by sortase (see Haft, et al., 2006). In at least six species, a gene encoding what appears to be a dedicated (single target) exosortase is adjacent. In that subset, the PEP-CTERM motif takes the form VPEPxxWxL. |
| References | DR TIGRFAMS; TIGR02595; PEP_anchor RN [1] RA Haft DH, Paulsen IT, Ward N, Selengut JD RT Exopolysaccharide-associated protein sorting in environmental organisms by the PEP-CTERM/EpsH system: application of a novel phylogenetic profiling heuristic. RL BMC Biol., in press, 2006 |