| Comment | Members of this family, hydroxyisourate hydrolase, represent a distinct clade of transthyretin-related proteins. Bacterial members typically are encoded next to ureidoglycolate hydrolase and often near either xanthine dehydrogenase or xanthine/uracil permease genes and have been demonstrated to have hydroxyisourate hydrolase activity [1]. In eukaryotes, a clade separate from the transthyretins (a family of thyroid-hormone binding proteins) has also been shown to have HIU hydrolase activity in urate catabolizing organisms [2]. Transthyretin, then, would appear to be the recently diverged paralog of the more ancient HIUH family. |
| References | RN [1]
RM PMID: 16098976
RT Transthyretin-related proteins function to facilitate the hydrolysis of 5-hydroxyisourate, the end product of the uricase reaction.
RA Lee Y, Lee do H, Kho CW, Lee AY, Jang M, Cho S, Lee CH, Lee JS, Myung PK, Park BC, Park SG
RL FEBS Lett. 2005 Aug 29;579(21):4769-74.
RN [2]
RM PMID: 17085964
RT Mouse Transthyretin-related Protein Is a Hydrolase which Degrades 5-Hydroxyisourate, the End Product of the Uricase Reaction.
RA Lee Y, Park BC, Lee do H, Bae KH, Cho S, Lee CH, Lee JS, Myung PK, Park SG
RL Mol Cells. 2006 Oct 31;22(2):141-5. |
