| Accession | TIGR03030 |
| Name | CelA |
| Function | cellulose synthase catalytic subunit (UDP-forming) |
| Gene Symbol | bcsA |
| Trusted Cutoff | 699.10 |
| Domain Trusted Cutoff | 699.10 |
| Noise Cutoff | 598.15 |
| Domain Noise Cutoff | 598.15 |
| Isology Type | equivalog_domain |
| EC Number | 2.4.1.12 |
| HMM Length | 714 |
| Author | Selengut J |
| Entry Date | Aug 1 2006 2:43PM |
| Last Modified | Jul 28 2012 7:29PM |
| Comment | Cellulose synthase catalyzes the beta-1,4 polymerization of glucose residues in the formation of cellulose. In bacteria, the substrate is UDP-glucose. The synthase consists of two subunits (or domains in the frequent cases where it is encoded as a single polypeptide), the catalytic domain modelled here and the regulatory domain (PF03170). The regulatory domain binds the allosteric activator cyclic di-GMP. The protein is membrane-associated and probably assembles into multimers such that the individual cellulose strands can self-assemble into multi-strand fibrils. |
| References | RN [1]
RM PMID: 2030672
RT Cellulose biosynthesis and function in bacteria.
RA Ross P, Mayer R, Benziman M
RL Microbiol Rev. 1991 Mar;55(1):35-58.
RN [2]
RM PMID: 8083166
RT Characterization of genes in the cellulose-synthesizing operon (acs operon) of Acetobacter xylinum: implications for cellulose crystallization.
RA Saxena IM, Kudlicka K, Okuda K, Brown RM Jr
RL J Bacteriol. 1994 Sep;176(18):5735-52. |
| Genome Property | GenProp0658: cellulose biosynthesis (HMM) |
