HMM Summary Page: TIGR03030

Functioncellulose synthase catalytic subunit (UDP-forming)
Gene SymbolbcsA
Trusted Cutoff699.10
Domain Trusted Cutoff699.10
Noise Cutoff598.15
Domain Noise Cutoff598.15
Isology Typeequivalog_domain
EC Number2.4.1.12
HMM Length714
AuthorSelengut J
Entry DateAug 1 2006 2:43PM
Last ModifiedJul 28 2012 7:29PM
CommentCellulose synthase catalyzes the beta-1,4 polymerization of glucose residues in the formation of cellulose. In bacteria, the substrate is UDP-glucose. The synthase consists of two subunits (or domains in the frequent cases where it is encoded as a single polypeptide), the catalytic domain modelled here and the regulatory domain (PF03170). The regulatory domain binds the allosteric activator cyclic di-GMP. The protein is membrane-associated and probably assembles into multimers such that the individual cellulose strands can self-assemble into multi-strand fibrils.
ReferencesRN [1] RM PMID: 2030672 RT Cellulose biosynthesis and function in bacteria. RA Ross P, Mayer R, Benziman M RL Microbiol Rev. 1991 Mar;55(1):35-58. RN [2] RM PMID: 8083166 RT Characterization of genes in the cellulose-synthesizing operon (acs operon) of Acetobacter xylinum: implications for cellulose crystallization. RA Saxena IM, Kudlicka K, Okuda K, Brown RM Jr RL J Bacteriol. 1994 Sep;176(18):5735-52.
Genome PropertyGenProp0658: cellulose biosynthesis (HMM)