|Domain Trusted Cutoff||114.95|
|Domain Noise Cutoff||60.30|
|Entry Date||Sep 28 2006 8:13AM|
|Last Modified||Feb 14 2011 3:27PM|
|Comment||Members of this protein family are the enzyme methylmalonyl-CoA epimerase (EC 22.214.171.124), also called methylmalonyl-CoA racemase. This enzyme converts (2R)-methylmalonyl-CoA to (2S)-methylmalonyl-CoA, which is then a substrate for methylmalonyl-CoA mutase (TIGR00642). It is known in bacteria, archaea, and as a mitochondrial protein in animals. It is closely related to lactoylglutathione lyase (TIGR00068), which is also called glyoxylase I, and is also a homodimer.|
RM PMID: 11481338
RT Identification of the human methylmalonyl-CoA racemase gene based on the analysis of prokaryotic gene arrangements. Implications for decoding the human genome.
RA Bobik TA, Rasche ME
RL J Biol Chem. 2001 Oct 5;276(40):37194-8.
RM PMID: 11470438
RT Crystal structure of methylmalonyl-coenzyme A epimerase from P. shermanii: a novel enzymatic function on an ancient metal binding scaffold.
RA McCarthy AA, Baker HM, Shewry SC, Patchett ML, Baker EN
RL Structure. 2001 Jul 3;9(7):637-46.
DR BRENDA; 126.96.36.199; Methylmalonyl-CoA epimerase
DR PFAM; PF00903; glyoxalase family protein|
|Genome Property||GenProp0755: pyruvate conversion to propionate, anaerobic, FAD/NAD-regenerating (HMM)|
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