| Accession | TIGR03119 |
| Name | one_C_fhcD |
| Function | formylmethanofuran--tetrahydromethanopterin N-formyltransferase |
| Gene Symbol | fhcD |
| Trusted Cutoff | 292.60 |
| Domain Trusted Cutoff | 292.60 |
| Noise Cutoff | 94.05 |
| Domain Noise Cutoff | 94.05 |
| Isology Type | equivalog |
| EC Number | 2.3.1.101 |
| HMM Length | 288 |
| Mainrole Category | Central intermediary metabolism |
| Subrole Category | One-carbon metabolism |
| Author | Haft DH |
| Entry Date | Oct 26 2006 10:48AM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | Members of this protein family are the FhcD protein of tetrahydromethanopterin (H4MPT)-dependent C-1 carrier metabolism. In the archaea, FhcD is designated formylmethanofuran--tetrahydromethanopterin N-formyltransferase, while in bacteria it is commonly designated as formyltransferase/hydrolase complex subunit D. FhcD is essential for one-carbon metabolism in at least three groups of prokaryotes: methanogenic archaea, sulfate-reducing archaea, and methylotrophic bacteria. |
| References | DR PFAM; PF01913; Formylmethanofuran--tetrahydromethanopterin formyltransferase, distal lobe
RN [1]
RM PMID: 16466742
RT The structure of formylmethanofuran: tetrahydromethanopterin formyltransferase in complex with its coenzymes.
RA Acharya P, Warkentin E, Ermler U, Thauer RK, Shima S
RL J Mol Biol. 2006 Mar 31;357(3):870-9. Epub 2006 Jan 23.
RN [2]
RM PMID: 16011764
RT Development and application of polymerase chain reaction primers based on fhcD for environmental detection of methanopterin-linked C1-metabolism in bacteria.
RA Kalyuzhnaya MG, Nercessian O, Lidstrom ME, Chistoserdova L
RL Environ Microbiol. 2005 Aug;7(8):1269-74.
DR HAMAP; MF_00579; 13 of 13 |
| Genome Property | GenProp0671: H4MPT-linked C1 transfer pathway (HMM) |
