HMM Summary Page: TIGR03124

Functionholo-ACP synthase CitX
Gene SymbolcitX
Trusted Cutoff105.25
Domain Trusted Cutoff105.25
Noise Cutoff57.15
Domain Noise Cutoff57.15
Isology Typeequivalog_domain
EC Number2.7.7.61
HMM Length165
Mainrole CategoryEnergy metabolism
Subrole CategoryFermentation
Gene Ontology TermGO:0050519: holo-citrate lyase synthase activity molecular_function
GO:0051191: prosthetic group biosynthetic process biological_process
AuthorHaft DH
Entry DateOct 28 2006 10:40PM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this protein family are the CitX protein, or CitX domain of the CitXG bifunctional protein, of the citrate lyase system. CitX transfers the prosthetic group 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA to the citrate lyase gamma chain, an acyl carrier protein. This enzyme may be designated holo-ACP synthase, holo-citrate lyase synthase, or apo-citrate lyase phosphoribosyl-dephospho-CoA transferase. In a few genera, including Haemophilus, this protein occurs as a fusion protein with CitG (, an enzyme involved in prosthetic group biosynthesis. This CitX family is easily separated from the holo-ACP synthases of other enzyme systems.
ReferencesRN [1] RM PMID: 11948157 RT Identification of a gene cluster in Klebsiella pneumoniae which includes citX, a gene required for biosynthesis of the citrate lyase prosthetic group. RA Schneider K, Kastner CN, Meyer M, Wessel M, Dimroth P, Bott M RL J Bacteriol. 2002 May;184(9):2439-46. DR HAMAP; MF_00398; 18 of 19
Genome PropertyGenProp0672: citrate lyase system (HMM)