|Domain Trusted Cutoff||293.45|
|Domain Noise Cutoff||223.60|
|Subrole Category||RNA processing|
|Gene Ontology Term||GO:0008616: queuosine biosynthetic process biological_process|
| ||GO:0033739: preQ1 synthase activity molecular_function|
| ||GO:0043867: 7-cyano-7-deazaguanine tRNA-ribosyltransferase activity molecular_function|
|Entry Date||Nov 2 2006 3:31PM|
|Last Modified||Feb 14 2011 3:27PM|
|Comment||This enzyme catalyzes the 4-electron reduction of the cyano group of 7-cyano-7-deazaguanine (preQ0) to an amine . Although related to a large family of GTP cyclohydrolases (PF01227), the relationship is structural and not germane to the catalytic mechanism. This mode represents the longer, gram-negative version of the enzyme as found in E. coli.
The enzymatic step represents the first point at which the biosynthesis of queuosine in bacteria and eukaryotes is distinguished from the biosynthesis of archaeosine in archaea.|
RM PMID: 15767583
RT From cyclohydrolase to oxidoreductase: discovery of nitrile reductase activity in a common fold.
RA Van Lanen SG, Reader JS, Swairjo MA, de Crecy-Lagard V, Lee B, Iwata-Reuyl D
RL Proc Natl Acad Sci U S A. 2005 Mar 22;102(12):4264-9. Epub 2005 Mar 14.
DR HAMAP; MF_00817; 137 of 139|
|Genome Property||GenProp0677: queuosine (Q-tRNA) biosynthesis from preQ0 (HMM)|
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