| Accession | TIGR03140 |
| Name | AhpF |
| Function | alkyl hydroperoxide reductase subunit F |
| Gene Symbol | ahpF |
| Trusted Cutoff | 502.90 |
| Domain Trusted Cutoff | 502.90 |
| Noise Cutoff | 400.10 |
| Domain Noise Cutoff | 400.10 |
| Isology Type | equivalog |
| EC Number | 1.8.1.- |
| HMM Length | 515 |
| Mainrole Category | Cellular processes |
| Subrole Category | Detoxification |
| Gene Ontology Term | GO:0006805: xenobiotic metabolic process biological_process |
| | GO:0009398: FMN biosynthetic process biological_process |
| | GO:0016668: oxidoreductase activity, acting on a sulfur group of donors, NAD or NADP as acceptor molecular_function |
| Author | Selengut J |
| Entry Date | Nov 2 2006 4:45PM |
| Last Modified | Jun 19 2012 9:42AM |
| Comment | This enzyme is the partner of the peroxiredoxin (alkyl hydroperoxide reductase) AhpC which contains the peroxide-reactive cysteine. AhpF contains the reductant (NAD(P)H) binding domain (PF00070) and presumably acts to resolve the disulfide which forms after oxidation of the active site cysteine in AphC [1]. This proteins contains two paired conserved cysteine motifs, CxxCP and CxHCDGP. |
| References | RN [1]
RM PMID: 10482511
RT Role of the alkyl hydroperoxide reductase (ahpCF) gene in oxidative stress defense of the obligate Anaerobe bacteroides fragilis.
RA Rocha ER, Smith CJ
RL J Bacteriol. 1999 Sep;181(18):5701-10. |
| Genome Property | GenProp0676: alkylhydroperoxide reductase AhpCF (peroxiredoxin) (HMM) |
