HMM Summary Page: TIGR03161

Functionalpha-ribazole phosphatase CobZ
Gene SymbolcobZ
Trusted Cutoff152.50
Domain Trusted Cutoff152.50
Noise Cutoff84.00
Domain Noise Cutoff84.00
Isology Typeequivalog
EC Number3.1.3.73
HMM Length140
Mainrole CategoryBiosynthesis of cofactors, prosthetic groups, and carriers
Subrole CategoryHeme, porphyrin, and cobalamin
Gene Ontology TermGO:0009236: cobalamin biosynthetic process biological_process
GO:0019175: alpha-ribazole-5'-P phosphatase activity molecular_function
AuthorHaft DH
Entry DateNov 16 2006 1:38PM
Last ModifiedFeb 14 2011 3:27PM
CommentSequences in the seed alignment were the experimentally characterized CobZ of the methanogenic archaeon Methanosarcina mazei, and other archaeal proteins found similarly next to or very near to other cobalamin biosynthesis genes. CobZ replaces the alpha-ribazole-phosphate phosphatase (EC called CobC in analogous bacterial pathways for cobalamin biosynthesis under anaerobic conditions.
ReferencesRN [1] RM PMID: 16547066 RT The cobZ gene of Methanosarcina mazei Go1 encodes the nonorthologous replacement of the alpha-ribazole-5'-phosphate phosphatase (CobC) enzyme of Salmonella enterica. RA Zayas CL, Woodson JD, Escalante-Semerena JC RL J Bacteriol. 2006 Apr;188(7):2740-3.
Genome PropertyGenProp0269: coenzyme B12 biosynthesis from cob(II)yrinate diamide (HMM)