HMM Summary Page: TIGR03197

AccessionTIGR03197
NameMnmC_Cterm
FunctiontRNA U-34 5-methylaminomethyl-2-thiouridine biosynthesis protein MnmC, C-terminal domain
Gene SymbolmnmC
Trusted Cutoff174.20
Domain Trusted Cutoff174.20
Noise Cutoff150.70
Domain Noise Cutoff150.70
Isology Typeequivalog_domain
HMM Length400
Mainrole CategoryProtein synthesis
Subrole CategorytRNA and rRNA base modification
AuthorHaft DH
Entry DateDec 11 2006 3:59PM
Last ModifiedFeb 14 2011 3:27PM
CommentIn Escherichia coli, the protein previously designated YfcK is now identified as the bifunctional enzyme MnmC. It acts, following the action of the heterotetramer of GidA and MnmE, in the modification of U-34 of certain tRNA to 5-methylaminomethyl-2-thiouridine (mnm5s2U). In other bacterial, the corresponding proteins are usually but always found as a single polypeptide chain, but occasionally as the product of tandem genes. This model represents the C-terminal region of the multifunctional protein.
ReferencesRN [1] RM PMID: 15247431 RT Identification of a bifunctional enzyme MnmC involved in the biosynthesis of a hypermodified uridine in the wobble position of tRNA. RA Bujnicki JM, Oudjama Y, Roovers M, Owczarek S, Caillet J, Droogmans L RL RNA. 2004 Aug;10(8):1236-42. Epub 2004 Jul 9. DR HAMAP; MF_01102; 107 of 174
Genome PropertyGenProp0704: tRNA U34 carboxymethylaminomethyl modification (HMM)