HMM Summary Page: TIGR03209

Functiontranscriptional regulator BotR, P-21
Gene SymbolbotR
Trusted Cutoff138.35
Domain Trusted Cutoff138.35
Noise Cutoff54.25
Domain Noise Cutoff54.25
Isology Typeequivalog
HMM Length142
AuthorPhillippy K, Selengut J
Entry DateDec 14 2006 2:31PM
Last ModifiedFeb 14 2011 3:27PM
CommentClostridium botulinum neurotoxin production is regulated by a regulatory sigma-70 protein, BotR transcription regulator. Similarly, tetanus toxin production of Clostridium tetani is regulated by TetR which is a very close relative of BotR. Both BotR and TetR are members of the TIGR02937 subfamily of sigma-70 RNA polymerase sigma factors. Functional complementation experiments have been done for botR and tetR in highly transformable strain of Clostridium perfringens host cells to assess functional interchangeability of sigma factors and it has been confirmed that they are interchangeable in vivo [3].
ReferencesRN [1] RM PMID: 15158256 RT Nucleotide sequence and transcriptional analysis of the type A2 neurotoxin gene cluster in Clostridium botulinum. RA Dineen SS, Bradshaw M, Karasek CE, Johnson EA RL FEMS Microbiol Lett. 2004 Jun 1;235(1):9-16. RN [2] RM PMID: 16701505 RT Organization and regulation of the neurotoxin genes in Clostridium botulinum and Clostridium tetani. RA Raffestin S, Marvaud JC, Cerrato R, Dupuy B, Popoff MR RL Anaerobe. 2004 Apr;10(2):93-100. RN [3] RM PMID: 16677313 RT Regulation of toxin and bacteriocin gene expression in Clostridium by interchangeable RNA polymerase sigma factors. RA Dupuy B, Raffestin S, Matamouros S, Mani N, Popoff MR, Sonenshein AL RL Mol Microbiol. 2006 May;60(4):1044-57.
Genome PropertyGenProp0707: botulinum toxin system (HMM)