|Function||transcriptional regulator BotR, P-21|
|Domain Trusted Cutoff||138.35|
|Domain Noise Cutoff||54.25|
|Author||Phillippy K, Selengut J|
|Entry Date||Dec 14 2006 2:31PM|
|Last Modified||Feb 14 2011 3:27PM|
|Comment||Clostridium botulinum neurotoxin production is regulated by a regulatory sigma-70 protein, BotR transcription regulator.
Similarly, tetanus toxin production of Clostridium tetani is regulated by TetR which is a very close relative of BotR. Both BotR and TetR are members of the TIGR02937 subfamily of sigma-70 RNA polymerase sigma factors. Functional complementation experiments have been done for botR and tetR in highly transformable strain of Clostridium perfringens host cells to assess functional interchangeability of sigma factors and it has been confirmed that they are interchangeable in vivo .|
RM PMID: 15158256
RT Nucleotide sequence and transcriptional analysis of the type A2 neurotoxin gene cluster in Clostridium botulinum.
RA Dineen SS, Bradshaw M, Karasek CE, Johnson EA
RL FEMS Microbiol Lett. 2004 Jun 1;235(1):9-16.
RM PMID: 16701505
RT Organization and regulation of the neurotoxin genes in Clostridium botulinum and Clostridium tetani.
RA Raffestin S, Marvaud JC, Cerrato R, Dupuy B, Popoff MR
RL Anaerobe. 2004 Apr;10(2):93-100.
RM PMID: 16677313
RT Regulation of toxin and bacteriocin gene expression in Clostridium by interchangeable RNA polymerase sigma factors.
RA Dupuy B, Raffestin S, Matamouros S, Mani N, Popoff MR, Sonenshein AL
RL Mol Microbiol. 2006 May;60(4):1044-57.|
|Genome Property||GenProp0707: botulinum toxin system (HMM)|
© J. Craig Venter Institute | Privacy Statement | Data Disclaimer