|Domain Trusted Cutoff||286.00|
|Domain Noise Cutoff||147.55|
|Mainrole Category||Energy metabolism|
|Gene Ontology Term||GO:0008701: 4-hydroxy-2-oxovalerate aldolase activity molecular_function|
|Entry Date||Dec 19 2006 9:00AM|
|Last Modified||Dec 12 2011 10:29PM|
|Comment||Members of this protein family are 4-hydroxy-2-oxovalerate aldolase, also called 4-hydroxy-2-ketovalerate aldolase and 2-oxo-4-hydroxypentanoate aldolase. This enzyme, part of the pathway for the meta-cleavage of catechol, produces pyruvate and acetaldehyde. Acetaldehyde is then converted by acetaldehyde dehydrogenase (acylating) (DmpF; EC 188.8.131.52) to acetyl-CoA. The two enzymes are tightly associated.|
RM PMID: 7496535
RT The 4-hydroxy-2-oxovalerate aldolase and acetaldehyde dehydrogenase (acylating) encoded by the nahM and nahO genes of the naphthalene catabolic plasmid pWW60-22 provide further evidence of conservation of meta-cleavage pathway gene sequences.
RA Platt A, Shingler V, Taylor SC, Williams PA
RL Microbiology. 1995 Sep;141 ( Pt 9):2223-33.
RM PMID: 12764229
RT Crystal structure of a bifunctional aldolase-dehydrogenase: sequestering a reactive and volatile intermediate.
RA Manjasetty BA, Powlowski J, Vrielink A
RL Proc Natl Acad Sci U S A. 2003 Jun 10;100(12):6992-7. Epub 2003 May 22.|
|Genome Property||GenProp0708: catechol meta-cleavage pathway (HMM)|
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