| Comment | Characterized members of this protein family are L-lysine 6-transaminase, also called lysine epsilon-aminotransferase (LAT). The immediate product of the reaction of this enzyme on lysine, 2-aminoadipate 6-semialdehyde, becomes 1-piperideine 6-carboxylate, or P6C. This product may be converted subsequently to pipecolate or alpha-aminoadipate, lysine catabolites that may be precursors of certain seconary metabolites. |
| References | RN [1]
RM PMID: 12005058
RT Biotransformation of L-lysine to L-pipecolic acid catalyzed by L-lysine 6-aminotransferase and pyrroline-5-carboxylate reductase.
RA Fujii T, Mukaihara M, Agematu H, Tsunekawa H
RL Biosci Biotechnol Biochem. 2002 Mar;66(3):622-7.
RN [2]
RM PMID: 9355735
RT Delta-1-piperideine-6-carboxylate dehydrogenase, a new enzyme that forms alpha-aminoadipate in Streptomyces clavuligerus and other cephamycin C-producing actinomycetes.
RA de La Fuente JL, Rumbero A, Martin JF, Liras P
RL Biochem J. 1997 Oct 1;327 ( Pt 1):59-64. |
