HMM Summary Page: TIGR03253

Functionformyl-CoA transferase
Gene Symbolfrc
Trusted Cutoff504.20
Domain Trusted Cutoff504.20
Noise Cutoff371.30
Domain Noise Cutoff371.30
Isology Typeequivalog
EC Number2.8.3.16
HMM Length416
Mainrole CategoryCellular processes
Subrole CategoryDetoxification
Gene Ontology TermGO:0005515: protein binding molecular_function
GO:0009636: response to toxin biological_process
GO:0033608: formyl-CoA transferase activity molecular_function
GO:0033611: oxalate catabolic process biological_process
AuthorHaft DH
Entry DateJan 12 2007 11:23AM
Last ModifiedFeb 14 2011 3:27PM
CommentThis enzyme, formyl-CoA transferase, transfers coenzyme A from formyl-CoA to oxalate. It forms a pathway, together with oxalyl-CoA decarboxylase, for oxalate degradation; decarboxylation by the latter gene regenerates formyl-CoA. The two enzymes typically are encoded by a two-gene operon.
ReferencesRN [1] RM PMID: 16517636 RT Transcriptional and functional analysis of oxalyl-coenzyme A (CoA) decarboxylase and formyl-CoA transferase genes from Lactobacillus acidophilus. RA Azcarate-Peril MA, Bruno-Barcena JM, Hassan HM, Klaenhammer TR RL Appl Environ Microbiol. 2006 Mar;72(3):1891-9. RN [2] RM PMID: 12844490 RT The crystal structure of the Escherichia coli YfdW gene product reveals a new fold of two interlaced rings identifying a wide family of CoA transferases. RA Gruez A, Roig-Zamboni V, Valencia C, Campanacci V, Cambillau C RL J Biol Chem. 2003 Sep 5;278(36):34582-6. Epub 2003 Jul 3.
Genome PropertyGenProp0718: oxalate degradation (HMM)