HMM Summary Page: TIGR03254

Functionoxalyl-CoA decarboxylase
Gene Symboloxc
Trusted Cutoff739.40
Domain Trusted Cutoff739.40
Noise Cutoff649.80
Domain Noise Cutoff649.80
Isology Typeequivalog
EC Number4.1.1.8
HMM Length554
Mainrole CategoryCellular processes
Subrole CategoryDetoxification
Gene Ontology TermGO:0000287: magnesium ion binding molecular_function
GO:0008949: oxalyl-CoA decarboxylase activity molecular_function
GO:0009636: response to toxin biological_process
GO:0033611: oxalate catabolic process biological_process
AuthorHaft DH
Entry DateJan 12 2007 1:08PM
Last ModifiedFeb 14 2011 3:27PM
CommentIn a number of bacteria, including Oxalobacter formigenes from the human gut, a two-gene operon of oxc (oxalyl-CoA decarboxylase) and frc (formyl-CoA transferase) encodes a system for degrading and therefore detoxifying oxalate. Members of this family are the thiamine pyrophosphate (TPP)-containing enzyme oxalyl-CoA decarboxylase.
ReferencesRN [1] RM PMID: 16517636 RT Transcriptional and functional analysis of oxalyl-coenzyme A (CoA) decarboxylase and formyl-CoA transferase genes from Lactobacillus acidophilus. RA Azcarate-Peril MA, Bruno-Barcena JM, Hassan HM, Klaenhammer TR RL Appl Environ Microbiol. 2006 Mar;72(3):1891-9. RN [2] RM PMID: 15345383 RT Characterization and heterologous expression of the oxalyl coenzyme A decarboxylase gene from Bifidobacterium lactis. RA Federici F, Vitali B, Gotti R, Pasca MR, Gobbi S, Peck AB, Brigidi P RL Appl Environ Microbiol. 2004 Sep;70(9):5066-73.
Genome PropertyGenProp0718: oxalate degradation (HMM)