| Accession | TIGR03254 |
| Name | oxalate_oxc |
| Function | oxalyl-CoA decarboxylase |
| Gene Symbol | oxc |
| Trusted Cutoff | 739.40 |
| Domain Trusted Cutoff | 739.40 |
| Noise Cutoff | 649.80 |
| Domain Noise Cutoff | 649.80 |
| Isology Type | equivalog |
| EC Number | 4.1.1.8 |
| HMM Length | 554 |
| Mainrole Category | Cellular processes |
| Subrole Category | Detoxification |
| Gene Ontology Term | GO:0000287: magnesium ion binding molecular_function |
| | GO:0008949: oxalyl-CoA decarboxylase activity molecular_function |
| | GO:0009636: response to toxin biological_process |
| | GO:0033611: oxalate catabolic process biological_process |
| Author | Haft DH |
| Entry Date | Jan 12 2007 1:08PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | In a number of bacteria, including Oxalobacter formigenes from the human gut, a two-gene operon of oxc (oxalyl-CoA decarboxylase) and frc (formyl-CoA transferase) encodes a system for degrading and therefore detoxifying oxalate. Members of this family are the thiamine pyrophosphate (TPP)-containing enzyme oxalyl-CoA decarboxylase. |
| References | RN [1]
RM PMID: 16517636
RT Transcriptional and functional analysis of oxalyl-coenzyme A (CoA) decarboxylase and formyl-CoA transferase genes from Lactobacillus acidophilus.
RA Azcarate-Peril MA, Bruno-Barcena JM, Hassan HM, Klaenhammer TR
RL Appl Environ Microbiol. 2006 Mar;72(3):1891-9.
RN [2]
RM PMID: 15345383
RT Characterization and heterologous expression of the oxalyl coenzyme A decarboxylase gene from Bifidobacterium lactis.
RA Federici F, Vitali B, Gotti R, Pasca MR, Gobbi S, Peck AB, Brigidi P
RL Appl Environ Microbiol. 2004 Sep;70(9):5066-73. |
| Genome Property | GenProp0718: oxalate degradation (HMM) |
