HMM Summary Page: TIGR03260
| Accession | TIGR03260 |
| Name | met_CoM_red_D |
| Function | methyl-coenzyme M reductase operon protein D |
| Gene Symbol | mcrD |
| Trusted Cutoff | 100.00 |
| Domain Trusted Cutoff | 100.00 |
| Noise Cutoff | 50.00 |
| Domain Noise Cutoff | 50.00 |
| Isology Type | equivalog |
| HMM Length | 150 |
| Mainrole Category | Energy metabolism |
| Subrole Category | Methanogenesis |
| Author | Haft DH |
| Entry Date | Jan 16 2007 10:06AM |
| Last Modified | May 17 2011 3:15PM |
| Comment | Members of this protein family are protein D, a non-structural protein, of the operon for methyl coenzyme M reductase, also called coenzyme-B sulfoethylthiotransferase (EC 2.8.4.1). That enzyme, with alpha, beta, and gamma subunits, catalyzes the last step in methanogenesis; it has several modified sites, so accessory proteins are expected. Several methanogens have encode two such enzymes, designated I and II; this model does not separate the isozymes. Proteins in this family are expressed at much lower levels than the methyl-coenzyme M reductase itself and associate and have been shown to form at least transient associations. The precise function is unknown. |
| References | RN [1] RM PMID: 8268197 RT Association of the mcrD gene product with methyl coenzyme M reductase in Methanococcus vannielii. RA Stroup D, Reeve JN RL Biochim Biophys Acta. 1993 Dec 8;1203(2):175-83. |
| Genome Property | GenProp0719: methyl-coenzyme M reductase (HMM) |
| GenProp0722: methanogenesis marker set (HMM) |