HMM Summary Page: TIGR03264

Functionmethyl-coenzyme M reductase I operon protein C
Gene SymbolmcrC
Trusted Cutoff213.50
Domain Trusted Cutoff213.50
Noise Cutoff51.55
Domain Noise Cutoff51.55
Isology Typeequivalog
HMM Length194
Mainrole CategoryEnergy metabolism
Subrole CategoryMethanogenesis
AuthorHaft DH
Entry DateJan 16 2007 3:54PM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this protein family are protein C, a non-structural protein, of the operon for methyl coenzyme M reductase, also called coenzyme-B sulfoethylthiotransferase (EC That enzyme, with alpha, beta, and gamma subunits, catalyzes the last step in methanogenesis; it has several modified sites, so accessory proteins are expected. Several methanogens have encode two such enzymes, designated I and II; this protein occurs only operons of type I. The precise function is unknown.
ReferencesRN [1] RM PMID: 8359675 RT Identification of the mcrC gene product in Methanococcus vannielii. RA Stroup D, Reeve JN RL FEMS Microbiol Lett. 1993 Jul 15;111(1):129-34. RN [2] RM PMID: 8177216 RT Characterization and phylogeny of mcrII, a gene cluster encoding an isoenzyme of methyl coenzyme M reductase from hyperthermophilic Methanothermus fervidus. RA Lehmacher A, Klenk HP RL Mol Gen Genet. 1994 Apr;243(2):198-206.
Genome PropertyGenProp0719: methyl-coenzyme M reductase (HMM)
GenProp0722: methanogenesis marker set (HMM)