HMM Summary Page: TIGR03301

AccessionTIGR03301
NamePhnW-AepZ
Function2-aminoethylphosphonate aminotransferase
Trusted Cutoff360.80
Domain Trusted Cutoff360.80
Noise Cutoff290.05
Domain Noise Cutoff290.05
Isology Typesubfamily
EC Number2.6.1.-
HMM Length355
AuthorSelengut J
Entry DateFeb 1 2007 1:38PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis family includes a number of 2-aminoethylphosphonate aminotransferases, some of which are indicated to operate in the catabolism of 2-aminoethylphosphonate (AEP) and others which are involved in the biosynthesis of the same compound. The catabolic enzyme (PhnW, [1]) is known to use pyruvate:alanine as the transfer partner and is modeled by the equivalog-level HMM (TIGR02326). The PhnW family is apparently a branch of a larger tree including genes (AepZ) adjacent to others responsible for the biosynthesis of phosphonoacetaldehyde [2]. The identity of the transfer partner is unknown for these enzymes and considering the reversed flux compared to PhnW, it may very well be different.
ReferencesRN [1] RM PMID: 12107130 RT The 2-aminoethylphosphonate-specific transaminase of the 2-aminoethylphosphonate degradation pathway. RA Kim AD, Baker AS, Dunaway-Mariano D, Metcalf WW, Wanner BL, Martin BM RL J Bacteriol. 2002 Aug;184(15):4134-40. RN [2] RM PMID: 11035722 RT Bacteroides fragilis NCTC9343 produces at least three distinct capsular polysaccharides: cloning, characterization, and reassignment of polysaccharide B and C biosynthesis loci. RA Coyne MJ, Kalka-Moll W, Tzianabos AO, Kasper DL, Comstock LE RL Infect Immun. 2000 Nov;68(11):6176-81.
Genome PropertyGenProp0724: phosphonoacetaldehyde biosynthesis from phosphoenolpyruvate (SUBFAMILY)
GenProp0724: phosphonoacetaldehyde biosynthesis from phosphoenolpyruvate (SUBFAMILY)
GenProp0724: phosphonoacetaldehyde biosynthesis from phosphoenolpyruvate (SUBFAMILY)
GenProp0724: phosphonoacetaldehyde biosynthesis from phosphoenolpyruvate (SUBFAMILY)
GenProp0724: phosphonoacetaldehyde biosynthesis from phosphoenolpyruvate (SUBFAMILY)
GenProp0724: phosphonoacetaldehyde biosynthesis from phosphoenolpyruvate (SUBFAMILY)