HMM Summary Page: TIGR03310

Functionmolybdenum cofactor cytidylyltransferase
Gene SymbolmocA
Trusted Cutoff186.45
Domain Trusted Cutoff186.45
Noise Cutoff182.80
Domain Noise Cutoff182.80
Isology Typeequivalog
EC Number2.7.7.76
HMM Length188
AuthorHaft DH
Entry DateFeb 13 2007 3:49PM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this protein include MocA, which transfers cytosine from CTP to molybdopterin during molybdopterin cytosine dinucleotide (MCD) cofactor biosynthesis. It is distantly related to MobA, the GTP:molybdopterin guanylyltransferase. The MocA family is particularly closely related in phylogenetic distribution to other markers of selenium-dependent molybdenum hydroxylases (SDMH), suggesting most SDMH must use MCD rather than molybdopterin guanine dinucleotide.
ReferencesRN [1] RM PMID:18289380 RT Orphan SelD proteins and selenium-dependent molybdenum hydroxylases. RA Haft DH, Self WT RL Biol Direct. 2008 Feb 20;3:4. RN [2] RM PMID:19542235 RT MocA is a specific cytidylyltransferase involved in molybdopterin cytosine dinucleotide biosynthesis in Escherichia coli. RA Neumann M, Mittelstadt G, Seduk F, Iobbi-Nivol C, Leimkuhler S RL J Biol Chem. 2009 Aug 14;284(33):21891-8.
Genome PropertyGenProp0726: selenium-dependent molybdenum hydroxylase system (HMM)