HMM Summary Page: TIGR03311

Functionselenium-dependent xanthine dehydrogenase
Gene Symbolxdh
Trusted Cutoff830.45
Domain Trusted Cutoff830.45
Noise Cutoff680.95
Domain Noise Cutoff680.95
Isology Typeequivalog
EC Number1.17.1.4
HMM Length848
AuthorHaft DH
Entry DateFeb 14 2007 3:59PM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this protein resemble conventional xanthine dehydrogenase enzymes, which depend on molybdenum cofactor - molybdopterin bound to molybdate with two sulfur atoms as ligands. But all members of this family occur in species that contain markers for the biosynthesis of enzymes with a selenium-containing form of molybdenum cofactor. The member of this family from Enterococcus faecalis has been shown to act as a xanthine dehydrogenenase, and its activity if dependent on SelD (selenophosphate synthase), selenium, and molybdenum.
ReferencesRN [1] RM PMID:21257770 RT A selenium-dependent xanthine dehydrogenase triggers biofilm proliferation in Enterococcus faecalis through oxidant production. RA Srivastava M, Mallard C, Barke T, Hancock LE, Self WT RL J Bacteriol. 2011 Apr;193(7):1643-52. doi: 10.1128/JB.01063-10. RN [2] RM PMID:18289380 RT Orphan SelD proteins and selenium-dependent molybdenum hydroxylases. RA Haft DH, Self WT RL Biol Direct. 2008 Feb 20;3:4. doi: 10.1186/1745-6150-3-4.
Genome PropertyGenProp0726: selenium-dependent molybdenum hydroxylase system (HMM)