|Function||selenium-dependent xanthine dehydrogenase|
|Domain Trusted Cutoff||830.45|
|Domain Noise Cutoff||680.95|
|Entry Date||Feb 14 2007 3:59PM|
|Last Modified||Feb 14 2011 3:27PM|
|Comment||Members of this protein resemble conventional xanthine dehydrogenase enzymes, which depend on molybdenum cofactor - molybdopterin bound to molybdate with two sulfur atoms as ligands. But all members of this family occur in species that contain markers for the biosynthesis of enzymes with a selenium-containing form of molybdenum cofactor. The member of this family from Enterococcus faecalis has been shown to act as a xanthine dehydrogenenase, and its activity if dependent on SelD (selenophosphate synthase), selenium, and molybdenum.|
RT A selenium-dependent xanthine dehydrogenase triggers biofilm proliferation in Enterococcus faecalis through oxidant production.
RA Srivastava M, Mallard C, Barke T, Hancock LE, Self WT
RL J Bacteriol. 2011 Apr;193(7):1643-52. doi: 10.1128/JB.01063-10.
RT Orphan SelD proteins and selenium-dependent molybdenum hydroxylases.
RA Haft DH, Self WT
RL Biol Direct. 2008 Feb 20;3:4. doi: 10.1186/1745-6150-3-4.|
|Genome Property||GenProp0726: selenium-dependent molybdenum hydroxylase system (HMM)|
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