HMM Summary Page: TIGR03329

Functionputative aminophosphonate oxidoreductase
Trusted Cutoff632.80
Domain Trusted Cutoff632.80
Noise Cutoff501.95
Domain Noise Cutoff501.95
Isology Typehypoth_equivalog
HMM Length460
AuthorSelengut J
Entry DateMar 2 2007 12:18PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis clade of sequences are members of the PF01266 family of FAD-dependent oxidoreductases. Characterized proteins within this family include glycerol-3-phosphate dehydrogenase (, sarcosine oxidase beta subunit ( and a number of deaminating amino acid oxidases (1.4.-.-). These genes have been consistently observed in a genomic context including genes for the import and catabolism of 2-aminoethylphosphonate (AEP). If the substrate of this oxidoreductase is AEP itself, then it is probably acting in the manner of a deaminating oxidase, resulting in the same product (phosphonoacetaldehyde) as the transaminase PhnW (TIGR02326), but releasing ammonia instead of coupling to pyruvate:alanine. Alternatively, it is reasonable to suppose that the various ABC cassette transporters which are also associated with these loci allow the import of phosphonates closely related to AEP which may not be substrates for PhnW.
Genome PropertyGenProp0720: 2-aminoethylphosphonate utilization (HMM)