|Function||IscR-regulated protein YhgI|
|Domain Trusted Cutoff||269.35|
|Domain Noise Cutoff||97.85|
|Mainrole Category||Biosynthesis of cofactors, prosthetic groups, and carriers|
|Gene Ontology Term||GO:0003674: molecular_function molecular_function|
| ||GO:0016226: iron-sulfur cluster assembly biological_process|
|Entry Date||Mar 12 2007 4:13PM|
|Last Modified||Feb 14 2011 3:27PM|
|Comment||IscR (TIGR02010) is an iron-sulfur cluster-binding transcriptional regulator (see Genome Property GenProp0138). Members of this protein family include YhgI, whose expression is under control of IscR, and show sequence similarity to IscA, a known protein of iron-sulfur cluster biosynthesis. These two lines of evidence strongly suggest a role as an iron-sulfur cluster biosynthesis protein. An older study designated this protein GntY and suggested a role for it and for the product of an adjacent gene, based on complementation studies, in gluconate utilization.|
|References||DR PF01521; Fe-S_biosyn; HesB-like domain
RM PMID: 16677314
RT IscR-dependent gene expression links iron-sulphur cluster assembly to the control of O2-regulated genes in Escherichia coli.
RA Giel JL, Rodionov D, Liu M, Blattner FR, Kiley PJ
RL Mol Microbiol. 2006 May;60(4):1058-75.
RM PMID: 9871335
RT The gluconate high affinity transport of GntI in Escherichia coli involves a multicomponent complex system.
RA Porco A, Alonso G, Isturiz T
RL J Basic Microbiol. 1998;38(5-6):395-404.|
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