|Function||VPLPA-CTERM protein sorting domain|
|Domain Trusted Cutoff||25.35|
|Domain Noise Cutoff||17.60|
|Entry Date||Mar 23 2007 3:05PM|
|Last Modified||Feb 10 2012 12:30PM|
|Comment||A probable protein export sorting signal, PEP-CTERM, was described by Haft, et al. (PMID:16930487). It is predicted to interact with a putative transpeptidase we designate exosortase. This model describes a variant with conserved motif VPLPA, rather than VPEP. It appears to be the recognition sequences for exosortase D (TIGR04152). This variant is found prominently in two members of the Rhodobacterales, namely Jannaschia sp. CCS1 and Roseobacter denitrificans OCh 114. One interesting member protein has a full-length duplication and therefore two copies of this putative sorting domain.|
RT Archaeosortases and exosortases are widely distributed systems linking membrane transit with posttranslational modification.
RA Haft DH, Payne SH, Selengut JD
RL J Bacteriol. 2012 Jan;194(1):36-48. Epub 2011 Oct 28.
RM PMID: 16930487
RT Exopolysaccharide-associated protein sorting in environmental organisms: the PEP-CTERM/EpsH system. Application of a novel phylogenetic profiling heuristic.
RA Haft DH, Paulsen IT, Ward N, Selengut JD
RL BMC Biol. 2006 Aug 24;4:29.|
|Genome Property||GenProp0986: protein sorting system, VPLPA-CTERM/exosortase D (HMM)|
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