HMM Summary Page: TIGR03384

Functiontranscriptional repressor BetI
Gene SymbolbetI
Trusted Cutoff201.30
Domain Trusted Cutoff201.30
Noise Cutoff127.70
Domain Noise Cutoff127.70
Isology Typeequivalog
HMM Length189
Mainrole CategoryRegulatory functions
Subrole CategoryDNA interactions
Gene Ontology TermGO:0016566: specific transcriptional repressor activity molecular_function
GO:0019285: glycine betaine biosynthetic process from choline biological_process
GO:0045892: negative regulation of transcription, DNA-dependent biological_process
AuthorHaft DH
Entry DateApr 17 2007 2:23PM
Last ModifiedFeb 14 2011 3:27PM
CommentBetI is a DNA-binding transcriptional repressor of the bet (betaine) regulon. In sequence, it is related to TetR (PF00440). Choline, through BetI, induces the expression of the betaine biosynthesis genes betA and betB by derepression. The choline porter gene betT is also part of this regulon in Escherichia coli. Note that a different transcriptional regulator, ArcA, controls the expression of bet regulon genes in response to oxygen, as BetA is an oxygen-dependent enzyme.
ReferencesRN [1] RM PMID: 9141699 RT Molecular characterization of the bet genes encoding glycine betaine synthesis in Sinorhizobium meliloti 102F34. RA Pocard JA, Vincent N, Boncompagni E, Smith LT, Poggi MC, Le Rudulier D RL Microbiology. 1997 Apr;143 ( Pt 4):1369-79.
Genome PropertyGenProp0147: glycine betaine biosynthesis from choline (HMM)