HMM Summary Page: TIGR03391

Functioncysteine desulfurase, sulfur acceptor subunit CsdE
Gene SymbolcsdE
Trusted Cutoff136.40
Domain Trusted Cutoff136.40
Noise Cutoff136.15
Domain Noise Cutoff136.15
Isology Typeequivalog
EC Number2.8.1.7
HMM Length139
Mainrole CategoryBiosynthesis of cofactors, prosthetic groups, and carriers
Subrole CategoryOther
Gene Ontology TermGO:0016226: iron-sulfur cluster assembly biological_process
GO:0031071: cysteine desulfurase activity molecular_function
AuthorHaft DH
Entry DateApr 23 2007 1:32PM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this protein family are CsdE, formerly called YgdK. This protein, found as a paralog to SufE in Escherichia coli, Yersinia pestis, Photorhabdus luminescens, and related species, works together and physically interacts with CsdA (a paralog of SufS). CsdA has cysteine desulfurase activity that is enhanced by this protein (CsdE), in which Cys-61 (numbered as in E. coli) is a sulfur acceptor site. This gene pair, although involved in FeS cluster biosynthesis, is not found next to other such genes as are its paralogs from the Suf or Isc systems.
ReferencesRN [1] RM PMID: 15901727 RT Analysis of the heteromeric CsdA-CsdE cysteine desulfurase, assisting Fe-S cluster biogenesis in Escherichia coli. RA Loiseau L, Ollagnier-de Choudens S, Lascoux D, Forest E, Fontecave M, Barras F RL J Biol Chem. 2005 Jul 22;280(29):26760-9.
Genome PropertyGenProp0739: iron-sulfur cluster assembly CsdA-CsdE system (HMM)