|Function||cysteine desulfurase NifS|
|Domain Trusted Cutoff||530.75|
|Domain Noise Cutoff||445.25|
|Entry Date||May 1 2007 3:47PM|
|Last Modified||Feb 14 2011 3:27PM|
|Comment||Members of this protein family are NifS, one of several related families of cysteine desulfurase involved in iron-sulfur (FeS) cluster biosynthesis. NifS is part of the NIF system, usually associated with other nif genes involved in nitrogenase expression and nitrogen fixation. The protein family is given a fairly broad interpretation here. It includes a clade nearly always found in extended nitrogen fixation genomic regions, plus a second clade more closely related to the first than to IscS and also part of NifS-like/NifU-like systems. This model does not extend to a more distantly clade found in the epsilon proteobacteria such as Helicobacter pylori, also named NifS in the literature, built instead in TIGR03403.|
RM PMID: 10639125
RT NifS-directed assembly of a transient [2Fe-2S] cluster within the NifU protein.
RA Yuvaniyama P, Agar JN, Cash VL, Johnson MK, Dean DR
RL Proc Natl Acad Sci U S A. 2000 Jan 18;97(2):599-604.RN 
RM PMID: 15667274
RT NifU and NifS are required for the maturation of nitrogenase and cannot replace the function of isc-gene products in Azotobacter vinelandii.
RA Johnson DC, Dos Santos PC, Dean DR
RL Biochem Soc Trans. 2005 Feb;33(Pt 1):90-3.|
|Genome Property||GenProp0742: iron-sulfur cluster assembly NIF system (HMM)|
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