|Function||succinate CoA transferase|
|Domain Trusted Cutoff||658.70|
|Domain Noise Cutoff||610.30|
|Entry Date||Jul 23 2007 11:12AM|
|Last Modified||Feb 21 2012 12:19PM|
|Comment||This family of CoA transferases includes enzymes catalyzing at least two related but distinct activities. The E. coli YgfH protein has been characterized as a propionyl-CoA:succinate CoA transferase  where it appears to be involved in a pathway for the decarboxylation of succinate to propionate. The Clostridium kluyveri CAT1 protein has been characterized as a acetyl-CoA:succinate CoA transferase  and is believed to be involved in anaerobic succinate degradation.
The propionate:succinate transferase activity has been reported in the propionic acid fermentation of propionibacterium species  where it is distinct from the coupled activities of distinct nucleotide-triphosphate dependent succinate and propionate/acetate CoA transferases (as inferred from activity in the absence of NTPs). The family represented by this model includes a member from Propionibacterium acnes KPA171202 which is likely to be responsible for this activity.
A closely related clade not included in this family are the Ach1p proteins of fungi which are acetyl-CoA hydrolases . This name has been applied to many of the proteins modeled by this HMM, possibly erroneously.|
RT Discovering new enzymes and metabolic pathways: conversion of succinate to propionate by Escherichia coli.
RA Haller T, Buckel T, Retey J, Gerlt JA
RL Biochemistry. 2000 Apr 25;39(16):4622-9.
RT Molecular analysis of the anaerobic succinate degradation pathway in Clostridium kluyveri.
RA Sohling B, Gottschalk G
RL J Bacteriol. 1996 Feb;178(3):871-80.
RT PURIFICATION AND PROPERTIES OF ENZYMES INVOLVED IN THE PROPIONIC ACID FERMENTATION.
RA ALLEN SH, KELLERMEYER RW, STJERNHOLM RL, WOOD HG
RL J Bacteriol. 1964 Jan;87:171-87.
RT Functional characterization and localization of acetyl-CoA hydrolase, Ach1p, in Saccharomyces cerevisiae.
RA Buu LM, Chen YC, Lee FJ
RL J Biol Chem. 2003 May 9;278(19):17203-9. Epub 2003 Feb 26.|
|Genome Property||GenProp0755: pyruvate conversion to propionate, anaerobic, FAD/NAD-regenerating (HMM)|
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