| Accession | TIGR03461 |
| Name | pabC_Proteo |
| Function | aminodeoxychorismate lyase |
| Gene Symbol | pabC |
| Trusted Cutoff | 176.85 |
| Domain Trusted Cutoff | 176.85 |
| Noise Cutoff | 152.05 |
| Domain Noise Cutoff | 152.05 |
| Isology Type | equivalog |
| EC Number | 4.1.3.38 |
| HMM Length | 262 |
| Mainrole Category | Biosynthesis of cofactors, prosthetic groups, and carriers |
| Subrole Category | Folic acid |
| Gene Ontology Term | GO:0008153: para-aminobenzoic acid biosynthetic process biological_process |
| | GO:0008696: 4-amino-4-deoxychorismate lyase activity molecular_function |
| | GO:0009396: folic acid-containing compound biosynthetic process biological_process |
| Author | Haft DH |
| Entry Date | Jul 30 2007 10:07AM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | Members of this protein family are aminodeoxychorismate lyase (ADC lyase), EC 4.1.3.38, the PabC protein of PABA biosynthesis. PABA (para-aminobenzoate) is a precursor of folate, needed for de novo purine biosynthesis. This enzyme is a pyridoxal-phosphate-binding protein in the class IV aminotransferase family (PF01063). |
| References | DR PFAM; PF01063; Aminotran_4; aminotransferase, class IV
RN [1]
RM PMID:1644759
RT Characterization and sequence of Escherichia coli pabC, the gene encoding aminodeoxychorismate lyase, a pyridoxal phosphate-containing enzyme.
RA Green JM, Merkel WK, Nichols BP
RL J Bacteriol. 1992 Aug;174(16):5317-23. |
| Genome Property | GenProp0759: para-aminobenzoic acid (PABA) biosynthesis from chorismate (HMM) |
