HMM Summary Page: TIGR03461

Functionaminodeoxychorismate lyase
Gene SymbolpabC
Trusted Cutoff176.85
Domain Trusted Cutoff176.85
Noise Cutoff152.05
Domain Noise Cutoff152.05
Isology Typeequivalog
EC Number4.1.3.38
HMM Length262
Mainrole CategoryBiosynthesis of cofactors, prosthetic groups, and carriers
Subrole CategoryFolic acid
Gene Ontology TermGO:0008153: para-aminobenzoic acid biosynthetic process biological_process
GO:0008696: 4-amino-4-deoxychorismate lyase activity molecular_function
GO:0009396: folic acid-containing compound biosynthetic process biological_process
AuthorHaft DH
Entry DateJul 30 2007 10:07AM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this protein family are aminodeoxychorismate lyase (ADC lyase), EC, the PabC protein of PABA biosynthesis. PABA (para-aminobenzoate) is a precursor of folate, needed for de novo purine biosynthesis. This enzyme is a pyridoxal-phosphate-binding protein in the class IV aminotransferase family (PF01063).
ReferencesDR PFAM; PF01063; Aminotran_4; aminotransferase, class IV RN [1] RM PMID:1644759 RT Characterization and sequence of Escherichia coli pabC, the gene encoding aminodeoxychorismate lyase, a pyridoxal phosphate-containing enzyme. RA Green JM, Merkel WK, Nichols BP RL J Bacteriol. 1992 Aug;174(16):5317-23.
Genome PropertyGenProp0759: para-aminobenzoic acid (PABA) biosynthesis from chorismate (HMM)