|Function||lycopene cyclase domain|
|Domain Trusted Cutoff||39.40|
|Domain Noise Cutoff||29.50|
|Entry Date||Jul 30 2007 2:02PM|
|Last Modified||Dec 21 2011 12:25PM|
|Comment||This domain is often repeated twice within the same polypeptide, as is observed in Archaea, Thermus, Sphingobacteria  and Fungi. In the fungal sequences, this tandem domain pair is observed as the N-terminal half of a bifunctional protein , where it has been characterized as a lycopene beta-cyclase and the C-terminal half is a phytoene synthetase. In Myxococcus and Actinobacterial genomes this domain appears as a single polypeptide, tandemly repeated and usually in a genomic context consistent with a role in carotenoid biosynthesis. It is unclear whether any of the sequences in this family truly encode lycopene epsilon cyclases. However a number are annotated as such.
The domain is generally hydrophobic with a number of predicted membrane spanning segments and contains a distinctive motif (hPhEEhhhhhh). In certain sequences one of either the proline or glutamates may vary, but always one of the tandem pair appear to match this canonical sequence exactly.|
RT A carotenoid synthesis gene cluster from Algoriphagus sp. KK10202C with a novel fusion-type lycopene beta-cyclase gene.
RA Tao L, Yao H, Kasai H, Misawa N, Cheng Q
RL Mol Genet Genomics. 2006 Jul;276(1):79-86. Epub 2006 Apr 20.
RT A bifunctional enzyme with lycopene cyclase and phytoene synthase activities is encoded by the carRP gene of Mucor circinelloides.
RA Velayos A, Eslava AP, Iturriaga EA
RL Eur J Biochem. 2000 Sep;267(17):5509-19.|
|Genome Property||GenProp0758: lycopene biosynthesis from IPP (HMM)|
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