HMM Summary Page: TIGR03467

Functionsqualene-associated FAD-dependent desaturase
Gene SymbolhpnE
Trusted Cutoff283.05
Domain Trusted Cutoff283.05
Noise Cutoff261.90
Domain Noise Cutoff261.90
Isology Typehypoth_equivalog
HMM Length430
AuthorSelengut J
Entry DateAug 8 2007 9:15AM
Last ModifiedFeb 14 2011 3:27PM
CommentThe sequences in this family are members of the PF01593 superfamily of flavin-containing amine oxidases which include the phytoene desaturases. These sequences also include a FAD-dependent oxidoreductase domain, PF01266. The genes of the family modeled here are generally in the same locus with genes involved in the biosynthesis and elaboration of squalene, the condensation product of the polyisoprenoid farnesyl pyrophosphate. This gene and its association with hopene biosynthesis in Zymomonas mobilis has been noted in the literature where the gene symbol hpnE was assigned [1]. This gene is also found in contexts where the downstream conversion of squalene to hopenes is not evidence. The precise nature of the reaction catalyzed by this enzyme is unknown at this time.
ReferencesRN [1] RM PMID:9714766 RT Cloning of conserved genes from Zymomonas mobilis and Bradyrhizobium japonicum that function in the biosynthesis of hopanoid lipids. RA Perzl M, Reipen IG, Schmitz S, Poralla K, Sahm H, Sprenger GA, Kannenberg EL RL Biochim Biophys Acta. 1998 Jul 31;1393(1):108-18.
Genome PropertyGenProp0761: hopanoid lipid biosynthesis (HMM)