HMM Summary Page: TIGR03468

Functionhopanoid-associated phosphorylase
Gene SymbolhpnG
Trusted Cutoff187.10
Domain Trusted Cutoff187.10
Noise Cutoff169.05
Domain Noise Cutoff169.05
Isology Typehypoth_equivalog
HMM Length212
AuthorSelengut J
Entry DateAug 8 2007 1:37PM
Last ModifiedFeb 14 2011 3:27PM
CommentThe sequences in this family are members of the PF01048 family of phosphorylases typically acting on nucleotide-sugar substrates. The genes of the family modeled here are generally in the same locus with genes involved in the biosynthesis and elaboration of hopene, the cyclization product of the polyisoprenoid squalene. This gene is adjacent to the genes PhnA-E and squalene-hopene cyclase (which would be HpnF) in Zymomonas mobilis and their association with hopene biosynthesis has been noted in the literature [1]. Extending the gene symbol sequence, we suggest the symbol HpnG for the product of this gene. Hopanoids are known to be components of the plasma membrane and to have polar sugar head groups in Z. mobilis and other species.
ReferencesRN [1] RM PMID:9714766 RT Cloning of conserved genes from Zymomonas mobilis and Bradyrhizobium japonicum that function in the biosynthesis of hopanoid lipids. RA Perzl M, Reipen IG, Schmitz S, Poralla K, Sahm H, Sprenger GA, Kannenberg EL RL Biochim Biophys Acta. 1998 Jul 31;1393(1):108-18.
Genome PropertyGenProp0761: hopanoid lipid biosynthesis (HMM)