HMM Summary Page: TIGR03504
| Accession | TIGR03504 |
| Name | FimV_Cterm |
| Function | FimV C-terminal domain |
| Gene Symbol | fimV |
| Trusted Cutoff | 30.65 |
| Domain Trusted Cutoff | 30.65 |
| Noise Cutoff | 23.45 |
| Domain Noise Cutoff | 23.45 |
| Isology Type | hypoth_equivalog_domain |
| HMM Length | 44 |
| Author | Haft DH |
| Entry Date | Nov 27 2007 11:41AM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | This protein is found at the extreme C-terminus of FimV from Pseudomonas aeruginosa, and of TspA of Neisseria meningitidis. Disruption of the former blocks twitching motility from type IV pili; Semmler, et al. suggest a role in peptidoglycan layer remodelling required by type IV fimbrial systems. |
| References | RN [1] RM PMID:10846211 RT Identification of a novel gene, fimV, involved in twitching motility in Pseudomonas aeruginosa. RA Semmler AB, Whitchurch CB, Leech AJ, Mattick JS RL Microbiology. 2000 Jun;146 ( Pt 6):1321-32. RN [2] RM PMID:10377136 RT Identification and characterization of TspA, a major CD4(+) T-cell- and B-cell-stimulating Neisseria-specific antigen. RA Kizil G, Todd I, Atta M, Borriello SP, Ait-Tahar K, Ala'Aldeen DA RL Infect Immun. 1999 Jul;67(7):3533-41. |