HMM Summary Page: TIGR03519

Functiontype IX secretion system membrane protein, PorP/SprF family
Trusted Cutoff90.55
Domain Trusted Cutoff90.55
Noise Cutoff73.05
Domain Noise Cutoff73.05
Isology Typesubfamily
HMM Length292
AuthorHaft DH, Selengut J
Entry DateDec 14 2007 4:25PM
Last ModifiedApr 15 2014 2:17PM
CommentThis HMM describes a protein family unique to, and greatly expanded in, the Bacteriodetes. Species in this lineage include several, such as Cytophaga hutchinsonii and Flavobacterium johnsoniae, that have type IX secretion systems (T9SS) and exhibit a poorly understood rapid gliding phenotype. Several members of this protein family are found in operons with other genes whose loss leads to a loss a this motility.
ReferencesRN [1] RM PMID:19966289 RT A protein secretion system linked to bacteroidete gliding motility and pathogenesis. RA Sato K, Naito M, Yukitake H, Hirakawa H, Shoji M, McBride MJ, Rhodes RG, Nakayama K RL Proc Natl Acad Sci U S A. 2010 Jan 5;107(1):276-81. doi: 10.1073/pnas.0912010107. RN [2] RM PMID:24257839 RT Deletion of the Cytophaga hutchinsonii type IX secretion system gene sprP results in defects in gliding motility and cellulose utilization. RA Zhu Y, McBride MJ RL Appl Microbiol Biotechnol. 2014 Jan;98(2):763-75. doi: 10.1007/s00253-013-5355-2.
Genome PropertyGenProp0781: gliding motility, Bacteroidetes type (HMM)