HMM Summary Page: TIGR03527

Functionselenium metabolism protein YedF
Gene SymbolyedF
Trusted Cutoff110.00
Domain Trusted Cutoff110.00
Noise Cutoff105.00
Domain Noise Cutoff105.00
Isology Typehypoth_equivalog
HMM Length194
AuthorHaft DH
Entry DateDec 20 2007 10:58AM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this protein family are about 200 amino acids in size, and include the uncharacterized YedF protein of Escherichia coli. This family shares an N-terminal domain, modeled by PF01206, with the sulfurtransferase TusA (also called SirA). The C-terminal domain includes a typical redox-active disulfide motif, CGXC. This protein family found only among those genomes that also carry the selenium donor protein SelD, and its connection to selenium metabolism is indicated by the method of partial phylogenetic profiling [1] vs. SelD. Its gene typically is found next to selD. Members of this family are found even when selenocysteine and selenouridine biosynthesis pathways are, except for SelD, completely absent, as in Enterococcus faecalis. Its role in selenium metabolism is unclear, but may include either detoxification or a role in labile selenoprotein biosynthesis.
ReferencesRN [1] RM PMID: 16930487 RT Exopolysaccharide-associated protein sorting in environmental organisms: the PEP-CTERM/EpsH system. Application of a novel phylogenetic profiling heuristic. RA Haft DH, Paulsen IT, Ward N, Selengut JD RL BMC Biol. 2006 Aug 24;4:29.
Genome PropertyGenProp0726: selenium-dependent molybdenum hydroxylase system (HMM)
GenProp0965: YedE/YedF selenium handling system (HMM)