| Accession | TIGR03531 |
| Name | selenium_SpcS |
| Function | O-phosphoseryl-tRNA(Sec) selenium transferase |
| Gene Symbol | spcS |
| Trusted Cutoff | 224.85 |
| Domain Trusted Cutoff | 224.85 |
| Noise Cutoff | 117.85 |
| Domain Noise Cutoff | 117.85 |
| Isology Type | equivalog |
| EC Number | 2.9.1.2 |
| HMM Length | 444 |
| Mainrole Category | Protein synthesis |
| Subrole Category | tRNA aminoacylation |
| Gene Ontology Term | GO:0016260: selenocysteine biosynthetic process biological_process |
| | GO:0016786: selenotransferase activity molecular_function |
| Author | Haft DH |
| Entry Date | Jan 1 2008 12:03PM |
| Last Modified | Dec 12 2011 10:42PM |
| Comment | In the archaea and eukaryotes, the conversion of the mischarged serine to selenocysteine (Sec) on its tRNA is accomplished in two steps. This enzyme, O-phosphoseryl-tRNA(Sec) selenium transferase, acts second, after a phosphophorylation step catalyzed by a homolog of the bacterial SelA protein. |
| References | RN [1]
RM PMID:17142313
RT RNA-dependent conversion of phosphoserine forms selenocysteine in eukaryotes and archaea.
RA Yuan J, Palioura S, Salazar JC, Su D, O'Donoghue P, Hohn MJ, Cardoso AM, Whitman WB, Soll D
RL Proc Natl Acad Sci U S A. 2006 Dec 12;103(50):18923-7. |
| Genome Property | GenProp0797: selenocysteinyl-tRNA, PSTK/SepSecS pathway (HMM) |
