HMM Summary Page: TIGR03549
Accession | TIGR03549 |
Name | TIGR03549 |
Function | YcaO domain protein |
Trusted Cutoff | 900.00 |
Domain Trusted Cutoff | 900.00 |
Noise Cutoff | 800.00 |
Domain Noise Cutoff | 800.00 |
Isology Type | hypoth_equivalog |
HMM Length | 723 |
Author | Haft DH |
Entry Date | Feb 29 2008 9:29AM |
Last Modified | Aug 14 2012 3:33PM |
Comment | This family consists of remarkably well-conserved proteins from gamma and beta Proteobacteria, heavily skewed towards organisms of marine environments. Its gene neighborhood is not conserved. This family has an OsmC-like N-terminal domain. It shares a YcaO domain, frequently associated with ATP-dependent cyclodehydration for peptide modification. The function is unknown. Fifteen of the first sixteen members of this family are from selenouridine-positive genomes, but this correlation may not be meaningful. |
References | RN [1] RM PMID:22522320 RT YcaO domains use ATP to activate amide backbones during peptide cyclodehydrations. RA Dunbar KL, Melby JO, Mitchell DA RL Nat Chem Biol. 2012 Apr 22;8(6):569-75. doi: 10.1038/nchembio.944. |