HMM Summary Page: TIGR03553

AccessionTIGR03553
NameF420_FbiB_CTERM
FunctionF420 biosynthesis protein FbiB, C-terminal domain
Gene SymbolfbiB
Trusted Cutoff249.55
Domain Trusted Cutoff249.55
Noise Cutoff77.75
Domain Noise Cutoff77.75
Isology Typeequivalog_domain
HMM Length194
Mainrole CategoryBiosynthesis of cofactors, prosthetic groups, and carriers
Subrole CategoryOther
Gene Ontology TermGO:0009108: coenzyme biosynthetic process biological_process
GO:0009108: coenzyme biosynthetic process biological_process
GO:0009108: coenzyme biosynthetic process biological_process
AuthorHaft DH
Entry DateMar 3 2008 1:49PM
Last ModifiedFeb 14 2011 3:27PM
CommentCoenzyme F420 differs between the Archaea and the Actinobacteria, where the numbers of glutamate residues attached are 2 (Archaea) or 5-6 (Mycobacterium). The enzyme in the Archaea is homologous to the N-terminal domain of FbiB from Mycobacterium bovis, and is responsible for glutamate ligation. Therefore it seems likely that the C-terminal domain of FbiB, modeled by this HMM, is involved in additional glutamate ligation.
ReferencesRN [1] RM PMID:18260642 RT Identification and Characterization of the 2-Phospho-l-lactate Guanylyltransferase Involved in Coenzyme F420 Biosynthesis. RA Grochowski LL, Xu H, White RH RL Biochemistry. 2008 Feb 9 RN [2] RM PMID:11717263 RT Use of transposon Tn5367 mutagenesis and a nitroimidazopyran-based selection system to demonstrate a requirement for fbiA and fbiB in coenzyme F(420) biosynthesis by Mycobacterium bovis BCG. RA Choi KP, Bair TB, Bae YM, Daniels L RL J Bacteriol. 2001 Dec;183(24):7058-66. RN [3] RM PMID:15215601 RT Identification and cloning of the gene involved in the final step of chlortetracycline biosynthesis in Streptomyces aureofaciens. RA Nakano T, Miyake K, Endo H, Dairi T, Mizukami T, Katsumata R RL Biosci Biotechnol Biochem. 2004 Jun;68(6):1345-52.
Genome PropertyGenProp0791: coenzyme F420 biosynthesis (HMM)
GenProp0791: coenzyme F420 biosynthesis (HMM)
GenProp0791: coenzyme F420 biosynthesis (HMM)