HMM Summary Page: TIGR03568
| Accession | TIGR03568 |
| Name | NeuC_NnaA |
| Function | UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing |
| Gene Symbol | neuC |
| Trusted Cutoff | 235.90 |
| Domain Trusted Cutoff | 235.90 |
| Noise Cutoff | 152.75 |
| Domain Noise Cutoff | 152.75 |
| Isology Type | equivalog |
| EC Number | 5.1.3.- 3.1.4.- |
| HMM Length | 365 |
| Author | Selengut J |
| Entry Date | Mar 19 2008 5:19PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | This family of enzymes catalyzes the combined epimerization and UDP-hydrolysis of UDP-N-acetylglucosamine to N-acetylmannosamine [1]. This is in contrast to the related enzyme WecB (TIGR00236) which retains the UDP moiety. NeuC acts in concert with NeuA and NeuB to synthesize CMP-N5-acetyl-neuraminate. |
| References | RN [1] RM PMID:14729696 RT The NeuC protein of Escherichia coli K1 is a UDP N-acetylglucosamine 2-epimerase. RA Vann WF, Daines DA, Murkin AS, Tanner ME, Chaffin DO, Rubens CE, Vionnet J, Silver RP RL J Bacteriol. 2004 Feb;186(3):706-12. |
| Genome Property | GenProp0793: CMP-N-acetylneuraminate biosynthesis from UDP-N-acetylglucosamine (HMM) |