| Accession | TIGR03574 |
| Name | selen_PSTK |
| Function | L-seryl-tRNA(Sec) kinase |
| Gene Symbol | pstK |
| Trusted Cutoff | 290.50 |
| Domain Trusted Cutoff | 290.50 |
| Noise Cutoff | 190.90 |
| Domain Noise Cutoff | 190.90 |
| Isology Type | equivalog |
| EC Number | 2.7.1.164 |
| HMM Length | 249 |
| Mainrole Category | Protein synthesis |
| Subrole Category | tRNA aminoacylation |
| Gene Ontology Term | GO:0016260: selenocysteine biosynthetic process biological_process |
| | GO:0016773: phosphotransferase activity, alcohol group as acceptor molecular_function |
| Author | Haft DH |
| Entry Date | Apr 7 2008 3:42PM |
| Last Modified | Dec 12 2011 11:11PM |
| Comment | Members of this protein are L-seryl-tRNA(Sec) kinase. This enzyme is part of a two-step pathway in Eukaryota and Archaea for performing selenocysteine biosynthesis by changing serine misacylated on selenocysteine-tRNA to selenocysteine. This enzyme performs the first step, phosphorylation of the OH group of the serine side chain. This family represents archaeal proteins with this activity. |
| References | RN [1]
RM PMID:18174226
RT Characterization and evolutionary history of an archaeal kinase involved in selenocysteinyl-tRNA formation.
RA Sherrer RL, O'Donoghue P, Soll D
RL Nucleic Acids Res. 2008 Mar;36(4):1247-59. |
| Genome Property | GenProp0797: selenocysteinyl-tRNA, PSTK/SepSecS pathway (HMM) |
