HMM Summary Page: TIGR03585

Functionpseudaminic acid biosynthesis N-acetyl transferase
Gene SymbolpseH
Trusted Cutoff93.10
Domain Trusted Cutoff93.10
Noise Cutoff81.60
Domain Noise Cutoff81.60
Isology Typehypoth_equivalog
HMM Length156
AuthorSelengut J
Entry DateApr 8 2008 5:17PM
Last ModifiedFeb 14 2011 3:27PM
CommentSequences in this family are members of the PF00583 (GNAT) superfamily of acetyltransferases and are proposed to perform a N-acetylation step in the process of pseudaminic acid biosynthesis in Campylobacter species [1]. This gene is commonly observed in apparent operons with other genes responsible for the biosynthesis of pseudaminic acid and as a component of flagellar and exopolysaccharide biosynthesis loci. Significantly, many genomes containing other components of this pathway lack this gene, indicating that some other N-acetyl transferases may be incolved and/or the step is optional, resulting in a non-acetylated pseudaminic acid variant sugar.
ReferencesRN [1] RM PMID:16684771 RT Functional characterization of the flagellar glycosylation locus in Campylobacter jejuni 81-176 using a focused metabolomics approach. RA McNally DJ, Hui JP, Aubry AJ, Mui KK, Guerry P, Brisson JR, Logan SM, Soo EC RL J Biol Chem. 2006 Jul 7;281(27):18489-98. Epub 2006 May 9.
Genome PropertyGenProp0796: CMP-pseudaminic acid biosynthesis from UDP-N-acetylglucosamine (HMM)