|Domain Trusted Cutoff||93.10|
|Domain Noise Cutoff||81.60|
|Author||Selengut J, Haft DH|
|Entry Date||Apr 8 2008 5:17PM|
|Last Modified||Jan 27 2014 11:21AM|
|Comment||Sequences in this family are members of the PF00583 (GNAT) superfamily of acetyltransferases and are proposed to perform a N-acetylation step in the process of pseudaminic acid biosynthesis in Campylobacter species . This gene is commonly observed in apparent operons with other genes responsible for the biosynthesis of pseudaminic acid and as a component of flagellar and exopolysaccharide biosynthesis loci. Significantly, many genomes containing other components of this pathway lack this gene, indicating that some other N-acetyl transferases may be incolved and/or the step is optional, resulting in a non-acetylated pseudaminic acid variant sugar.|
RT Structural and functional analysis of Campylobacter jejuni PseG: a udp-sugar hydrolase from the pseudaminic acid biosynthetic pathway.
RA Rangarajan ES, Proteau A, Cui Q, Logan SM, Potetinova Z, Whitfield D, Purisima EO, Cygler M, Matte A, Sulea T, Schoenhofen IC
RL J Biol Chem. 2009 Jul 31;284(31):20989-1000. doi: 10.1074/jbc.M109.012351.
RT Functional characterization of the flagellar glycosylation locus in Campylobacter jejuni 81-176 using a focused metabolomics approach.
RA McNally DJ, Hui JP, Aubry AJ, Mui KK, Guerry P, Brisson JR, Logan SM, Soo EC
RL J Biol Chem. 2006 Jul 7;281(27):18489-98. Epub 2006 May 9.|
|Genome Property||GenProp0796: CMP-pseudaminic acid biosynthesis from UDP-N-acetylglucosamine (HMM)|
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