HMM Summary Page: TIGR03586

Functionpseudaminic acid synthase
Gene SymbolpseI
Trusted Cutoff340.25
Domain Trusted Cutoff340.25
Noise Cutoff340.05
Domain Noise Cutoff340.05
Isology Typeequivalog
EC Number2.5.1.97
HMM Length327
AuthorSelengut J
Entry DateApr 8 2008 10:13PM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this family are included within the larger PF03102 (NeuB) family. NeuB itself (TIGR03569) is involved in the biosynthesis of neuraminic acid by the condensation of phosphoenolpyruvate (PEP) with N-Acetyl-D-Mannosamine. In an analagous reaction, this enzyme, PseI [1], condenses PEP with 6-deoxy-beta-L-AltNAc4NAc to generate pseudaminic acid.
ReferencesRN [1] RM PMID:16684771 RT Functional characterization of the flagellar glycosylation locus in Campylobacter jejuni 81-176 using a focused metabolomics approach. RA McNally DJ, Hui JP, Aubry AJ, Mui KK, Guerry P, Brisson JR, Logan SM, Soo EC RL J Biol Chem. 2006 Jul 7;281(27):18489-98. Epub 2006 May 9.
Genome PropertyGenProp0796: CMP-pseudaminic acid biosynthesis from UDP-N-acetylglucosamine (HMM)