HMM Summary Page: TIGR03589

AccessionTIGR03589
NamePseB
FunctionUDP-N-acetylglucosamine 4,6-dehydratase (inverting)
Gene SymbolpseB
Trusted Cutoff407.75
Domain Trusted Cutoff407.75
Noise Cutoff407.60
Domain Noise Cutoff407.60
Isology Typeequivalog
EC Number4.2.1.115
HMM Length324
AuthorSelengut J
Entry DateApr 9 2008 2:55PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis enzyme catalyzes the first step in the biosynthesis of pseudaminic acid, the conversion of UDP-N-acetylglucosamine to UDP-4-keto-6-deoxy-N-acetylglucosamine. These sequences are members of the broader PF01073 (3-beta hydroxysteroid dehydrogenase/isomerase family) family.
ReferencesRN [1] RM PMID:16684771 RT Functional characterization of the flagellar glycosylation locus in Campylobacter jejuni 81-176 using a focused metabolomics approach. RA McNally DJ, Hui JP, Aubry AJ, Mui KK, Guerry P, Brisson JR, Logan SM, Soo EC RL J Biol Chem. 2006 Jul 7;281(27):18489-98. Epub 2006 May 9. RN [2] RM PMID:17893902 RT CMP-Pseudaminic Acid is a Natural Potent Inhibitor of PseB, the First Enzyme of the Pseudaminic Acid Pathway in Campylobacter jejuni and Helicobacter pylori. RA McNally DJ, Schoenhofen IC, Houliston RS, Khieu NH, Whitfield DM, Logan SM, Jarrell HC, Brisson JR RL ChemMedChem. 2008 Jan 11;3(1):55-59. RN [3] RM PMID:16286454 RT Functional characterization of dehydratase/aminotransferase pairs from Helicobacter and Campylobacter: enzymes distinguishing the pseudaminic acid and bacillosamine biosynthetic pathways. RA Schoenhofen IC, McNally DJ, Vinogradov E, Whitfield D, Young NM, Dick S, Wakarchuk WW, Brisson JR, Logan SM RL J Biol Chem. 2006 Jan 13;281(2):723-32. Epub 2005 Nov 11. RN [4] RM PMID:14960321 RT Characterization of CJ1293, a new UDP-GlcNAc C6 dehydratase from Campylobacter jejuni. RA Creuzenet C RL FEBS Lett. 2004 Feb 13;559(1-3):136-40. RN [5] RM PMID:14617187 RT Pseudaminic acid, the major modification on Campylobacter flagellin, is synthesized via the Cj1293 gene. RA Goon S, Kelly JF, Logan SM, Ewing CP, Guerry P RL Mol Microbiol. 2003 Oct;50(2):659-71.
Genome PropertyGenProp0796: CMP-pseudaminic acid biosynthesis from UDP-N-acetylglucosamine (HMM)
GenProp0796: CMP-pseudaminic acid biosynthesis from UDP-N-acetylglucosamine (HMM)