HMM Summary Page: TIGR03601

Functionbacteriocin, heterocycloanthracin/sonorensin family
Trusted Cutoff35.00
Domain Trusted Cutoff35.00
Noise Cutoff33.00
Domain Noise Cutoff27.00
Isology Typesubfamily
HMM Length88
Mainrole CategoryCellular processes
Subrole CategoryToxin production and resistance
AuthorHaft DH
Entry DateMay 1 2008 4:14PM
Last ModifiedMar 12 2014 10:00AM
CommentNumerous bacteria encode systems for producing bacteriocins by extensive modification of ribosomally produced precursors. Members of the TOMM class (thiazole/oxazole-modified microcins) are recognizable by association with cyclodehydratase (and often dehydrogenase) maturation proteins. This family consists of a special subclass, the heterocycloanthracin family, that share a homologous leader peptide region and then a repeat region with Cys as every third residue. In Bacillus anthracis and Bacillus cereus, the RiPP (ribosomally translated and post-translationally modified natural product) precursor is encoded far from its maturase genes, and every strain has the system. In other species (e.g. B. licheniformis, B. sorenensis), precursor and maturase genes are close together. Sonorensin, from B. sonorensis MT93, was shown to have broad spectrum antimicrobial activity, affecting Gram-positive and Gram-negative bacteria.
ReferencesRN [1] RM PMID:19383135 RT A strain-variable bacteriocin in Bacillus anthracis and Bacillus cereus with repeated Cys-Xaa-Xaa motifs. RA Haft DH RL Biol Direct. 2009 Apr 21;4(1):15.
Genome PropertyGenProp0807: bacteriocin system, heterocycle biosynthesis group (HMM)