HMM Summary Page: TIGR03602

Functionbacteriocin protoxin, streptolysin S family
Trusted Cutoff39.95
Domain Trusted Cutoff39.95
Noise Cutoff17.80
Domain Noise Cutoff17.80
Isology Typesubfamily
HMM Length56
Mainrole CategoryCellular processes
Subrole CategoryToxin production and resistance
Gene Ontology TermGO:0003674: molecular_function molecular_function
GO:0005575: cellular_component cellular_component
GO:0019835: cytolysis biological_process
AuthorHaft DH
Entry DateMay 2 2008 8:58AM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this family are bacteriocin precursors. These small, ribosomally produced polypeptide precursors are extensively processed post-translationally. This family belongs to a class of heterocycle-containing bacteriocins, including streptolysin S from Streptococcus pyogenes, and related bacteriocins from Streptococcus iniae and Clostridium botulinum. Streptolysin S is hemolytic. Bacteriocin genes in general are small and highly diverse, with odd sequence composition, and are easily missed by many gene-finding programs.
ReferencesRN [1] RM PMID:18375757 RT Discovery of a widely distributed toxin biosynthetic gene cluster. RA Lee SW, Mitchell DA, Markley AL, Hensler ME, Gonzalez D, Wohlrab A, Dorrestein PC, Nizet V, Dixon JE RL Proc Natl Acad Sci U S A. 2008 Apr 15;105(15):5879-84.
Genome PropertyGenProp0807: bacteriocin system, heterocycle biosynthesis group (HMM)