| Accession | TIGR03602 |
| Name | streptolysinS |
| Function | bacteriocin protoxin, streptolysin S family |
| Trusted Cutoff | 39.95 |
| Domain Trusted Cutoff | 39.95 |
| Noise Cutoff | 17.80 |
| Domain Noise Cutoff | 17.80 |
| Isology Type | subfamily |
| HMM Length | 56 |
| Mainrole Category | Cellular processes |
| Subrole Category | Toxin production and resistance |
| Gene Ontology Term | GO:0003674: molecular_function molecular_function |
| | GO:0005575: cellular_component cellular_component |
| | GO:0019835: cytolysis biological_process |
| Author | Haft DH |
| Entry Date | May 2 2008 8:58AM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | Members of this family are bacteriocin precursors. These small, ribosomally produced polypeptide precursors are extensively processed post-translationally. This family belongs to a class of heterocycle-containing bacteriocins, including streptolysin S from Streptococcus pyogenes, and related bacteriocins from Streptococcus iniae and Clostridium botulinum. Streptolysin S is hemolytic. Bacteriocin genes in general are small and highly diverse, with odd sequence composition, and are easily missed by many gene-finding programs. |
| References | RN [1]
RM PMID:18375757
RT Discovery of a widely distributed toxin biosynthetic gene cluster.
RA Lee SW, Mitchell DA, Markley AL, Hensler ME, Gonzalez D, Wohlrab A, Dorrestein PC, Nizet V, Dixon JE
RL Proc Natl Acad Sci U S A. 2008 Apr 15;105(15):5879-84. |
| Genome Property | GenProp0807: bacteriocin system, heterocycle biosynthesis group (HMM) |
