Accession | TIGR03602 |
Name | streptolysinS |
Function | bacteriocin protoxin, streptolysin S family |
Trusted Cutoff | 39.95 |
Domain Trusted Cutoff | 39.95 |
Noise Cutoff | 17.80 |
Domain Noise Cutoff | 17.80 |
Isology Type | subfamily |
HMM Length | 56 |
Mainrole Category | Cellular processes |
Subrole Category | Toxin production and resistance |
Gene Ontology Term | GO:0003674: molecular_function molecular_function |
| GO:0005575: cellular_component cellular_component |
| GO:0019835: cytolysis biological_process |
Author | Haft DH |
Entry Date | May 2 2008 8:58AM |
Last Modified | Feb 14 2011 3:27PM |
Comment | Members of this family are bacteriocin precursors. These small, ribosomally produced polypeptide precursors are extensively processed post-translationally. This family belongs to a class of heterocycle-containing bacteriocins, including streptolysin S from Streptococcus pyogenes, and related bacteriocins from Streptococcus iniae and Clostridium botulinum. Streptolysin S is hemolytic. Bacteriocin genes in general are small and highly diverse, with odd sequence composition, and are easily missed by many gene-finding programs. |
References | RN [1]
RM PMID:18375757
RT Discovery of a widely distributed toxin biosynthetic gene cluster.
RA Lee SW, Mitchell DA, Markley AL, Hensler ME, Gonzalez D, Wohlrab A, Dorrestein PC, Nizet V, Dixon JE
RL Proc Natl Acad Sci U S A. 2008 Apr 15;105(15):5879-84. |
Genome Property | GenProp0807: bacteriocin system, heterocycle biosynthesis group (HMM) |