| Accession | TIGR03603 |
| Name | cyclo_dehy_ocin |
| Function | thiazole/oxazole-forming peptide maturase, SagC family component |
| Trusted Cutoff | 187.65 |
| Domain Trusted Cutoff | 187.65 |
| Noise Cutoff | 55.20 |
| Domain Noise Cutoff | 55.20 |
| Isology Type | subfamily |
| EC Number | 6.3.-.- |
| HMM Length | 319 |
| Mainrole Category | Cellular processes |
| Subrole Category | Pathogenesis |
| Gene Ontology Term | GO:0016882: cyclo-ligase activity molecular_function |
| | GO:0030152: bacteriocin biosynthetic process biological_process |
| Author | Haft DH |
| Entry Date | May 2 2008 12:22PM |
| Last Modified | Aug 14 2012 2:44PM |
| Comment | Members of this protein family include enzymes related to SagC, a protein involved in thiazole/oxazole cyclodehydration modifications during biosynthesis of streptolysin S in Streptococcus pyogenes from the protoxin polypeptide (product of the sagA gene). Recent evidence suggests that the YcaO/SagD-like component, not this component, performs an ATP-dependent cyclodehydration. This protein family serves as a marker for widely distributed prokaryotic systems for making a general class of heterocycle-containing bacteriocins. Note that this model does not find all possible examples of bacteriocin biosynthesis cyclodehydratases, an in particular misses the E. coli plasmid protein McbB of microcin B17 biosynthesis. |
| References | RN [1]
RM PMID:22522320
RT YcaO domains use ATP to activate amide backbones during peptide cyclodehydrations.
RA Dunbar KL, Melby JO, Mitchell DA
RL Nat Chem Biol. 2012 Apr 22;8(6):569-75.
RN [2]
RM PMID:18375757
RT Discovery of a widely distributed toxin biosynthetic gene cluster.
RA Lee SW, Mitchell DA, Markley AL, Hensler ME, Gonzalez D, Wohlrab A, Dorrestein PC, Nizet V, Dixon JE
RL Proc Natl Acad Sci U S A. 2008 Apr 15;105(15):5879-84. |
| Genome Property | GenProp0807: bacteriocin system, heterocycle biosynthesis group (HMM) |
